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KMID : 0387820120190020064
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Clinical Pediatric Hematology-Oncology
2012 Volume.19 No. 2 p.64 ~ p.71
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olecular Pathologic Classification of Medulloblastoma
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Lee Youn-Soo
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Abstract
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Medulloblastoma is the most frequent malignant brain tumor in children. Current ther-apeutic stratification for medulloblastoma is based on age, metastases, extent of re-section, and histological variants. Recent molecular pathologic studies have suggested that medulloblastoma is not a single disease but consists of multiple distinct molecular subgroups. The consensus conference concludes four main subgroups, termed as WNT, SHH, Group 3 and Group 4. The subgroups differ in demographics, clinical presentation, transcriptional profile, genetic abnormality, and clinical outcome. The identification of molecular subgroup will lead to the optimal treatment and more targeted therapy for these patients. The molecular classification of medulloblastoma will continue to diversify as larger cohorts and be applicable to the prospective clinical trials. This review outlines the differences between the medulloblastoma subgroups.
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KEYWORD
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Medulloblastoma, Molecular subgroups, WNT, SHH, Group 3, Group 4
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